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目的 :研究端粒酶逆转录酶 (humantelomerasereversetranscriptase ,hTERT)在低度恶性多形性腺癌中的表达及其意义。方法 : 原位杂交方法检测 13例低度恶性多形性腺癌及癌旁正常腺体组织中hTERT表达情况。结果 :9例初发肿瘤、4例复发肿瘤和癌旁正常组织hTERT阳性表达率分别为 78%(7/9) ,75 %(3/4)和 8%(1/13) ,癌旁正常腺体组织hTERT表达率低于肿瘤中hTERT表达 (p <0 .0 5 ) ;初发和复发肿瘤hTERT相比无差异 (p >0 .0 5 )。结论 :hTERT在多形性低度恶性腺癌中呈高表达 ,hTERT在初发及复发的多形性低度恶性腺癌中表达无差异。
Objective: To study the expression and significance of human telomerase reverse transcriptase (hTERT) in low grade malignant pleomorphic adenocarcinoma. Methods: In situ hybridization was used to detect the expression of hTERT in 13 cases of low grade malignant pleomorphic adenocarcinomas and adjacent normal glands. Results: The positive rates of hTERT in 9 cases of primary tumor, 4 cases of recurrent tumor and adjacent normal tissue were 78% (7/9), 75% (3/4) and 8% (1/13), respectively, The expression of hTERT in gland tissue was lower than that in tumor (p <0.05). There was no difference in hTERT between primary and recurrent tumors (p> 0.05). Conclusion: hTERT is highly expressed in pleomorphic low grade adenocarcinoma, hTERT is no difference in primary and recurrent pleomorphic low grade adenocarcinoma.