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最近的报告表明,移植物抗宿主病(GVHD)似乎有明显的抗肿瘤作用,并且接受自体骨髓移植(ABMT)及环孢霉素(CyA)治疗可出现与GVHD 相似的综合征。为此作者应用相似方法对12例血液系统恶性肿瘤病人进行了观察。5例ALL、2例晚期HD、5例CML 原始细胞危象病人,在ABMT 或造血干细胞移植(BSCT)治疗后当日开始接受CyA 治疗,CyA1.5mg/kg/d 静滴,连用28天,用药期间每日进行GVHD 临床分级及肝肾功能评定,每周进行病毒培养及血清学检测。发现皮疹后行皮肤活检组织学检查。
Recent reports suggest that graft-versus-host disease (GVHD) appears to have a significant anti-tumor effect and that similar syndromes to GVHD may occur with autologous bone marrow transplantation (ABMT) and cyclosporine (CyA) treatment. To this end the author applied a similar method of 12 cases of hematological malignancies were observed. Five patients with ALL, two patients with advanced HD and five patients with CML crisis were treated with CyA on the day following ABMT or HSCT treatment. CyA 1.5 mg / kg / d was intravenously administered for 28 days During the daily GVHD clinical grade and liver function evaluation, weekly virus culture and serological testing. Skin rashes were found after biopsy histological examination.