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1991年3月27日,日本厚生省发表的《医药品副作用情报》报道,广泛应用的中药制剂——小柴胡汤,在使用中发生了二例由该药物引起的间质性肺炎,且停药后肺炎消失,再用则又复发.由于其因果关系清楚,厚生省在当天就向津村和钟纺等二十多家制药厂家发出指示:在小柴胡汤的使用中应予注意,发生间质性肺炎虽极少见,但一旦出现副作用症状时,就应立即停止用药.小柴胡汤系治疗肝功能障碍药物,估计每年有100万人使用该药.1990年4月,曾有过使
On March 27th, 1991, the “Pharmaceutical Side Effects Information” published by the Ministry of Health and Welfare of Japan reported that the widely used Chinese medicine preparation Xiaochaihu Decoction had occurred in the use of two cases of interstitial pneumonia caused by the drug and the withdrawal of the drug. After the pneumonia disappeared, it relapsed afterwards. Because of its causality, the Ministry of Health and Health issued instructions to more than 20 pharmaceutical manufacturers such as Tsumura and Zhongfang on the same day: Attention should be paid to the use of Xiaochaihu Tang and interstitial Although pneumonia is rare, once the symptoms of side effects appear, it should be stopped immediately. Xiaochaihu Decoction treats liver dysfunction drugs. It is estimated that 1 million people use the drug every year. In April 1990, there were