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本文对28例严重先天性中枢神经系统(CNS)解剖缺陷新生儿的脑室液检测进行初步观察。其中4例至少有1种血清型的B组柯萨奇病毒(CVB)中和抗体。4例中的2例血清中未检出同一抗体。1例脑室中有抗CVB_6-IgM.11对母婴血清有CVB中和抗体,近半数抗体是直接抗1种以上的血清型。以上所见提示先天性CVB感染与严重CNS解剖缺陷之间可能有关。作者复习了有关文献后指出,CVB是广泛存在的病毒。很少导致先天性疾病和死胎,CVB特别与先天性心脏病有关。CNS感染则以无菌性脑膜炎为多见。急性CNS疾病仕院婴儿,约5%为肠道病毒,其中多数是CV。此数值可能低于实际发病率。因为CVB的亚临床感染是极其多见的。正常0～4岁婴儿的血清,因为存在有对已知CVB血清型的中和抗体,
In this paper, 28 cases of severe congenital central nervous system (CNS) anatomical defects in neonatal ventricular fluid testing was initially observed. Four of the four patients had at least one serotype B coxsackievirus (CVB) neutralizing antibody. Two of the four cases did not detect the same antibody in the serum. CVB_6-IgM.11 in one of the ventricles has CVB neutralizing antibody to maternal and infant serum, and nearly half of antibodies are directly against one or more serotypes. The above findings suggest that congenital CVB infection may be related to severe CNS anatomic defects. The author reviewed the literature and pointed out that CVB is a widespread virus. CVB is particularly associated with congenital heart disease, with few congenital and fetal deaths. CNS infection is more common with aseptic meningitis. Acute CNS disease hospital baby, about 5% of enterovirus, most of them CV. This value may be lower than the actual incidence. Because subclinical CVB infection is extremely common. Normal 0 to 4-year-old infant serum, because there is a known CVB serotype neutralizing antibodies,