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目的探讨急性脑梗死(ACI)患者血清超敏C反应蛋白(hs-CRP)含量的变化与疾病轻重的关系。方法测定105例ACI患者与105例健康体检者的血清hs-CRP含量并进行对比分析。结果治疗前ACI患者hs-CRP明显增高(11.53±2.3)mg/L,健康体检者hs-CRP为(2.34±1.15)mg/L,两组经统计学比较有显著性差异(P<0.01),ACI患者经治疗后2周开始下降,于6个月后逐渐趋于较稳定水平,但仍高于正常健康人群;且与健康人群比较有统计学意义(P<0.05)。②hs-CRP含量与神经功能缺损程度呈正相关,轻度hs-CRP含量(7.12±1.55)mg/L,中度hs-CRP含量为(13.11±1.64)mg/L,重度hs-CRP含量为(18.99±1.67)mg/L。结论脑梗死发生后hs-CRP含量明显升高,且含量高低与脑梗死病情的严重程度呈正相关,动态监测hs-CRP含量对于急性脑梗死的诊断、病情分度和监测和预后评估具有实用价值。
Objective To investigate the relationship between the change of serum hs-CRP and severity of disease in patients with acute cerebral infarction (ACI). Methods The serum hs-CRP levels in 105 patients with ACI and 105 healthy controls were measured and compared. Results The hs-CRP was significantly increased (11.53 ± 2.3) mg / L in ACI patients before treatment and hs-CRP in healthy subjects was (2.34 ± 1.15) mg / L, the difference was statistically significant (P <0.01) . The ACI patients began to decline at 2 weeks after treatment, gradually stabilized to a stable level after 6 months, but still higher than that of normal healthy people; and compared with healthy people (P <0.05). The content of hs-CRP was positively correlated with the degree of neurological deficit. The mild hs-CRP level was 7.12 ± 1.55 mg / L, the moderate hs-CRP level was (13.11 ± 1.64) mg / L, 18.99 ± 1.67) mg / L. Conclusions The content of hs-CRP in cerebral infarction is obviously increased after cerebral infarction, and the content of hs-CRP is positively correlated with the severity of cerebral infarction. The dynamic monitoring of hs-CRP has practical value in the diagnosis, prognosis and monitoring of prognosis of acute cerebral infarction .