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目的分析广州市2005年肾综合征出血热(HFRS)的流行特点和趋势,为制定防治策略提供依据。方法收集广州地区疫情资料,描述其流行病学特征。HFRS抗体与抗原检测采用免疫荧光分析。结果广州市2005年共检出HFRS患者75例,年发病率0·80/10万,死亡1例,年死亡率0·01/10万,病死率1·33%。病例多为青壮年男性工人、民工和商业服务者,主要分布于海珠和天河等地,发病高峰主要在春秋季。鼠间疫情监测显示鼠密度为11·7%,总带毒率为4·1%(26/632),优势鼠为褐家鼠,带毒率为5·4%(17/315)。结论广州HFRS疫情有上升趋势,流行因素广泛存在,应继续加大疫情监测力度,认真做好防鼠灭鼠及重点人群的疫苗接种工作。
Objective To analyze the epidemiological characteristics and trends of hemorrhagic fever with renal syndrome (HFRS) in Guangzhou in 2005 and provide the basis for the development of prevention and treatment strategies. Methods The data of epidemic situation in Guangzhou were collected and their epidemiological characteristics were described. HFRS antibody and antigen detection using immunofluorescence analysis. Results A total of 75 HFRS patients were detected in Guangzhou in 2005 with an annual incidence rate of 0.880 / 100,000 and 1 death. The annual mortality rate was 0.01 / 100,000 and the case fatality rate was 1.33%. Cases are mostly young male workers, migrant workers and commercial service providers, mainly distributed in Haizhu and Tianhe and other places, the peak incidence in the spring and autumn. The outbreak surveillance showed that the rat density was 11.7% and the total virulence rate was 4.1% (26/632). The predominant mouse was Rattus norvegicus, with a virus loading rate of 5.4% (17/315). Conclusion The epidemic situation of HFRS in Guangzhou is on an upward trend, and epidemic factors are widespread. We should continue to intensify the surveillance of epidemic situation and do a good job in anti-rodent control and vaccination of key populations.