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采用放免法测定了108例脑血管病(CVD)患者的血浆降钙素基因相关肽(CGRP)水平。结果62例脑梗塞(CI)患者(CI组)显著低于对照组,发病24小时内即显著降低,2～7天进一步降低;8～15天开始升高,15天后逐渐升至正常水平;46例脑出血(CH)患者(CH组)亦显著低于对照组,发病15天以内的变化规律同CI组;发病15天虽进一步升高,但仍低于正常水平。提示随病情加重,脑出血量或梗塞面积增加,血浆CGRP水平明显降低。认为CI、CH患者存在CGRP分泌异常,CGRP参与了CVD的病理生理过程;CGRP水平动态检测可作为估计病情严重程度、病灶大小及预后的重要指标,调整CGRP的分泌将有助于改善CVD患者的预后。
The levels of plasma calcitonin gene-related peptide (CGRP) in 108 patients with cerebrovascular disease (CVD) were measured by radioimmunoassay. Results Sixty-two patients with cerebral infarction (CI) were significantly lower than those in the control group. The incidence of CI decreased significantly within 24 hours and further decreased from 2 to 7 days. The levels of CI increased from 8 to 15 days and gradually rose to normal levels after 15 days. In 46 CH patients, the CH group was significantly lower than that of the control group. The change pattern within 15 days after onset was the same as that of CI group. Although it increased further on the 15th day, it was still lower than the normal level. Prompted with the aggravation of the situation, cerebral hemorrhage or infarct size increased plasma CGRP levels were significantly lower. It is considered that CGRP is abnormally expressed in patients with CI and CH, and CGRP is involved in the pathophysiological process of CVD. Dynamic detection of CGRP levels can be used as an important index to estimate the severity of the disease, the size of the lesion and prognosis. Adjusting the secretion of CGRP will help to improve CVD patients Prognosis.