基底细胞癌,又称基底细胞上皮瘤,是皮肤的恶性上皮瘤,可能有起源于表皮及其附件的基底细胞。近年来的研究发现,一些与凋亡有关的基因如 p53、Bax、bcl-x 及增殖细胞核抗原等在基底细胸癌中表达异常,提示基底细胞癌可能有异常的细胞凋亡。bcl-2是与细胞凋亡关系密切的原癌基因之一,p16为近年发现的新的抑癌基因,我们采用免疫组化技术对30例基底细胞癌组织中细胞凋亡相 Basal cell carcinoma, also known as basal cell epithelial tumor, is a malignant epithelial tumor of the skin that may have basal cells that originate in the epidermis and its attachments. Recent studies have found that some genes involved in apoptosis, such as p53, Bax, bcl-x and proliferating cell nuclear antigen, are abnormally expressed in basal breast carcinoma, suggesting that basal cell carcinoma may have abnormal apoptosis. Bcl-2 is one of the proto-oncogenes closely related to apoptosis. p16 is a new tumor suppressor gene discovered in recent years. We used immunohistochemistry to detect apoptosis in 30 cases of basal cell carcinoma.