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非甾体类抗炎药(NSAIDs)是临床上应用最广泛的药物之一,常用于各类炎症、发热以及疼痛症状的缓解。NSAIDs主要通过抑制环氧化酶(COX)介导的前列腺素合成起作用,选择性抑制COX-2会引起水钠潴留,导致血压升高。同时,NSAIDs与β肾上腺素受体阻滞剂、肾素-血管紧张素转换酶抑制剂、血管紧张素受体Ⅱ阻滞剂和利尿剂一起合用,可使高血压患者的血压升高,同时拮抗抗高血压药物的降压作用,从而增加高血压相关的发病率、死亡率风险以及护理费用。现拟对非甾体类抗炎药与高血压风险的研究进展作一综述。
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used drugs in clinic and are commonly used in various types of inflammation, fever and pain relief. NSAIDs primarily act by inhibiting cyclooxygenase (COX) -mediated prostaglandin synthesis, and selective inhibition of COX-2 causes sodium and water retention, resulting in elevated blood pressure. In the meantime, NSAIDs are used in combination with beta adrenergic blockers, renin-angiotensin-converting enzyme inhibitors, angiotensin II blockers and diuretics to raise blood pressure in hypertensive patients Antagonizes the antihypertensive effect of antihypertensives, thereby increasing the incidence of hypertension-related, mortality, and cost of care. The research progress of non-steroidal anti-inflammatory drugs and the risk of hypertension is hereby reviewed.