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目的了解新疆阿克苏地区中老年人群高尿酸血症患病情况,分析高尿酸血症相关危险因素。方法采用整群随机抽样的方法进行横断面调查,以当地1 534名40岁以上居民为调查对象,进行问卷调查、体格检查及实验室检测,收集个人基本情况,测定体质指数(BMI),并检测血糖、血压、血脂等代谢指标,建立二元logistic回归模型分析高尿酸血症的危险因素。结果该地区中老年人群总体患病率为13.23%,其中男性患病率为12.39%,血尿酸平均水平为(326.20±87.57)μmol/L;女性患病率为14.21%,血尿酸平均水平为(261.13±88.01)μmol/L。高尿酸血症与其他代谢性疾病密切相关(P<0.05);随着代谢性综合征诊断标准中疾病种类的增多,血尿酸水平呈显著上升趋势(F=187.63,P<0.05);二元logistic回归分析显示民族、年龄、超重肥胖、高血糖、高密度脂蛋白胆固醇(HDL-C)、高血压、吸烟是高尿酸血症的危险因素(P<0.05)。结论新疆阿克苏地区高尿酸血症患病率均较低,代谢综合征对高尿酸血症影响显著,及早防治代谢综合征对降低本地区高尿酸血症患病率具有重要意义。
Objective To understand the prevalence of hyperuricemia in middle-aged and elderly people in Aksu, Xinjiang and to analyze the risk factors associated with hyperuricemia. Methods A total of 1 534 residents over the age of 40 were enrolled in the study. A total of 1 534 residents over the age of 40 were investigated by questionnaires, physical examinations and laboratory tests. Basic personal information, body mass index (BMI) and The blood glucose, blood pressure, blood lipid and other metabolic indexes were detected, and the binary logistic regression model was established to analyze the risk factors of hyperuricemia. Results The overall prevalence of middle-aged and elderly people in this area was 13.23%, of which the prevalence was 12.39% in males and 326.20 ± 87.57 μmol / L in females, and 14.21% in females. The average level of serum uric acid was (261.13 ± 88.01) μmol / L. Hyperuricemia was closely related to other metabolic diseases (P <0.05). With the increase of disease types in the diagnostic criteria of metabolic syndrome, serum uric acid levels showed a significant upward trend (F = 187.63, P <0.05) Logistic regression analysis showed that ethnicity, age, overweight and obesity, hyperglycemia, high density lipoprotein cholesterol (HDL-C), hypertension and smoking were the risk factors of hyperuricemia (P <0.05). Conclusions The prevalence of hyperuricemia is low in Aksu region of Xinjiang. Metabolic syndrome has significant effect on hyperuricemia. It is of great importance to prevent and treat metabolic syndrome as early as possible to reduce the prevalence of hyperuricemia in this area.