以往探讨肠道,肝脏和肺在口服药物的第一关卡效应时常用不同给药途径的比较方法,通过比较药一时曲线下面积来研究各脏器在第一关卡效中作用。口服给药和门静脉给药可以判断肠壁的作用;门静脉给药和静脉给药可以研究肝的作用;静脉给药和动脉给药可以研究肺的作用。但所有上述方法仅仅是间接的方法。肠—肝灌流方法则是近年发展起来的新技 In the past to explore the intestinal, liver and lungs in the first barrier effect of oral drugs often use different routes of administration of comparative methods, by comparing the moment under the curve area to study the role of the organ in the first check effect. Oral and portal administration can determine the role of the intestinal wall; portal and intravenous administration can study the role of the liver; intravenous and arterial administration can study the role of the lung. But all the above methods are just indirect methods. Intestinal - liver perfusion method is developed in recent years, new skills