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帕金森病(PD)是中老年人常见的中枢神经系统变性疾病。其主要病理改变是由基底神经节中的黑质多巴胺能神经元变性、缺失和黑质-纹状体通路变性引起的,临床表现为静止性震颤、肌僵直和运动迟缓等症状。基底神经节作为锥体外系统中的运动调节中心,与许多核团之间存在着纤维联系。研究证实中缝背核(DRN)与基底神经节及PD的关系密切,现就DRN与基底神经节及PD的关系简要综述。
Parkinson’s disease (PD) is a common central nervous system degenerative disease in the elderly. The main pathological changes are the degeneration and deletion of substantia nigra dopaminergic neurons in the basal ganglia and the degeneration of the substantia nigra and striatum. The clinical manifestations are the symptoms of rest tremor, muscle rigidity and bradykinesia. The basal ganglia serve as a center of motor regulation in the extrapyramidal system and have a fiber connection with many nuclei. Study confirmed that the dorsal raphe (DRN) and basal ganglia and PD are closely related to the DRN and basal ganglia and PD are briefly summarized.