目的 :观察阿霉素白蛋白磁纳米粒在正常肝脏中的磁靶向性 ,并观察阿霉素白蛋白磁纳米粒在全身各脏器的分布特征。方法 :大鼠正中开腹 ,胃十二指肠动脉插管固定。实验组 :左肝外叶加磁场 ,肝动脉注射阿霉素白蛋白磁纳米粒 (相当于阿霉素 0 .5mg/kg) ,磁场应用 30min ,移去磁场后 ,动物立即处死。对照组 :左肝外叶外不加磁场 ,肝动脉注射同等剂量的纳米粒后 30min处死。动物处死后 ,立即取靶区肝、非靶区肝、心、肾、脾、肺、小肠和胃作γ计数。肝组织作组织学切片。结果 :左肝外叶应用磁场 30min后 ,磁区肝组织的放射活性较非磁区肝组织的放射活性明显增加 (P <0 .0 0 0 1) ,磁区肝组织与非磁区肝组织的放射活性比值为 2 .6。而对照组磁区肝组织与非磁区肝组织的放射活性之间无统计学差异。肝外脏器的放射活性明显降低。除实验组肺的放射活性较对照组明显下降外 ,其它脏器两组之间没有统计学差异。另外 ,实验组 :心、肾、脾、肺和小肠与靶区肝组织的放射活性比值较对照组明显降低。胃与靶区肝组织的放射活性比值两组之间无统计学差异。注入纳米粒的 70 %～ 80 %分布于肝脏 ,其它脏器含量极少。病理切片显示磁区小动脉中见大量纳米粒存在 ,对照组及非磁区肝中纳米粒很少见。结论 :阿霉素白蛋白磁纳米粒在? Objective: To observe the magnetic targeting of adriamycin albumin magnetic nanoparticles in normal liver, and to observe the distribution characteristics of doxorubicin albumin magnetic nanoparticles in all organs of the body. Methods: The rat was opened in the middle of the stomach and the gastroduodenal artery was cannulated. Experimental group: left hepatic lobe plus magnetic field, hepatic artery injection of doxorubicin albumin magnetic nanoparticles (equivalent to doxorubicin 0.5 mg/kg), magnetic field application for 30 min, removal of the magnetic field, the animals were immediately executed. In the control group, no magnetic field was applied outside the left hepatic lobe, and the hepatic artery was sacrificed 30 minutes after the injection of the same dose of nanoparticles. Immediately after the animals were sacrificed, gamma counts were taken from liver, heart, kidney, spleen, lungs, small intestine and stomach of the target liver and non-target areas. Liver tissue was histologically sectioned. RESULTS: After 30 min of magnetic field application in the left hepatic lobe, the radioactivity of the hepatic tissue in the magnetic domain was significantly higher than that in the non-magnetic region (P < 0.01), and the radioactivity ratio of the hepatic tissue to the non-magnetic region in the magnetic domain was significantly increased. It is 2.6. However, there was no statistical difference between the radioactivity of the liver tissue in the magnetic zone and the non-magnetic zone in the control group. Extrahepatic organ radioactivity was significantly reduced. Except that the radioactivity of the experimental group was significantly lower than that of the control group, there was no statistical difference between the other organs. In addition, the radioactivity ratio of liver tissue in the experimental group: heart, kidney, spleen, lung, small intestine and target area was significantly lower than that in the control group. There was no statistical difference between the radioactivity ratios of liver and stomach in the two groups. 70% to 80% of the injected nanoparticles are distributed in the liver, and other organs are rare. Pathological sections revealed the presence of a large number of nanoparticles in the small arterioles of the magnetic field. The control group and the non-magnetic region of the liver were rare. Conclusion: Doxorubicin albumin magnetic nanoparticles in?