目的探讨血清25羟基维生素D[25-(OH)D]与乳腺癌根治术后疾病不确定感、抑郁、焦虑情绪的关系。方法收集62例乳腺癌根治术患者为观察组,同期健康体检者40例为对照组。比较两组Mishel疾病不确定量表(MUIS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分及血清25-(OH)D水平。结果观察组的MUIS各维度评分、HAMA、HAMD评分均显著高于对照组,血清25-(OH)D水平显著低于对照组(P<0.05);血清25-(OH)D水平与MIUS、HAMA、HAMD评分呈显著负相关性(r=-0.398、-0.498、-0.421,P<0.05)。结论乳腺癌根治术患者术后普遍存在疾病不确定感及焦虑抑郁情绪,且其与低血清25-(OH)D水平密切相关。 Objective To investigate the relationship between serum 25-hydroxyvitamin D [25- (OH) D] and uncertainty, depression and anxiety in patients with breast cancer after radical operation. Methods Totally 62 patients undergoing radical mastectomy were selected as the observation group and 40 healthy subjects were selected as the control group. The Mishel Disease Indeterminate Scale (MUIS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Rating Scale (HAMD) and serum 25- (OH) D levels were compared between the two groups. Results The scores of MUIS, HAMA and HAMD in observation group were significantly higher than those in control group, and the serum 25- (OH) D levels in observation group were significantly lower than those in control group (P <0.05) HAMA, HAMD score was significantly negatively correlated (r = -0.398, -0.498, -0.421, P <0.05). Conclusion Uncertainty and anxiety and depression are common in patients undergoing radical mastectomy and are closely related to the level of 25- (OH) D in serum.