奎宁、奎尼丁是一类有效的抗疟药物,在东南亚地区仍在广泛使用。然而,奎宁、奎尼丁经非口服途径进入体内后,其清除和分布常常呈现异常,因此有必要监测其血浆药物浓度。作者研究了一种特异性强、敏感性高的高压液相色谱法,用以测定血浆奎宁和奎尼丁的浓度. Quinine, quinidine is an effective anti-malarial drug, is still widely used in Southeast Asia. However, after quinine and quinidine are parenterally introduced into the body, their clearance and distribution are often abnormal. Therefore, it is necessary to monitor their plasma drug concentration. The authors studied a highly specific and sensitive high-pressure liquid chromatography for the determination of plasma quinine and quinidine concentrations.