论文部分内容阅读
舍他康唑[7-氯-3-[1-(2,4-二氯苯基)-2-(1H-咪唑-1-基)乙氧基甲基]苯并[b]噻吩]是新的抗真菌合成药。在体外实验模型和在体内受广谱真菌主要为皮真菌(毛癣菌属、小孢子菌属、表皮癣菌属)、致病酵母(白色念珠菌、热带念珠菌、糠秕马拉色氏霉菌)和曲霉属感染的实验动物中都已表明有强效抗真菌作用。对各种动物的急性、亚急性和慢性毒性研究证明了舍他康唑的广泛耐受性。通过临床Ⅱ期试验以测定多剂量舍他康唑的耐受性和药动学,并评价它的皮肤吸收。对
Sertaconazole [7-chloro-3- [1- (2,4-dichlorophenyl) -2- (1H- imidazol-1-yl) ethoxymethyl] benzo [b] thiophene] is New antifungal synthetic drug. In vitro experimental models and in vivo by the broad-spectrum fungi are mainly dermatophytes (Trichophyton, Microsporum, Epidermophyton), pathogenic yeast (Candida albicans, Candida tropicalis, bran Malassezia furfur ) And Aspergillus infections in animals have been shown to have a potent antifungal effect. Acute, subacute, and chronic toxicity studies on various animals have demonstrated the broad tolerability of sertaconazole. Phase II clinical trials were conducted to determine the tolerability and pharmacokinetics of multiple dose of sertaconazole and to assess its skin absorption. Correct