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目的：研究大黄素对四氯化碳性肝损伤的保护作用。方法：采用４０％四氯化碳（ＣＣｌ４）给大鼠皮下注射 诱导肝损伤并以小、中和大剂量大黄素（２０、４０和 ８０ｍｇ／ｋｇ体重）治疗，（ １）通过常规方法测定大鼠血清谷丙转 氨酶（ＡＬＴ）、碱性磷酸酶（ＡＫＰ）、总蛋白（ＴＰ）、白蛋白（ＡＬＢ）及球蛋白（Ｇ）；（２）通过电镜观察肝细胞形态。结果： （１）与模型组比较，大黄素组大鼠血清 ＡＬＴ及 ＡＫＰ显著降低（ Ｐ＜ ０．０５～ ０．０１）， ＴＰ及 ＡＬＢ显著升高（Ｐ＜ ０．０５～ ０．０１），Ｇ降低，但无统计学差异；（２）形态学检查，大黄素组肝细胞损伤明显减轻。结论：大黄素对四氯化碳性 肝损伤具有保护作用。
Objective: To study the protective effect of emodin on carbon tetrachloride-induced liver injury. METHODS: Rats were injected subcutaneously with 40% carbon tetrachloride (CCl4) to induce liver injury and treated with small, medium, and high doses of emodin (20, 40, and 80 mg/kg body weight), (1) measured by conventional methods. Serum alanine aminotransferase (ALT), alkaline phosphatase (AKP), total protein (TP), albumin (ALB) and globulin (G); (2) The morphology of hepatocytes was observed by electron microscopy. Results: (1)Compared with the model group, serum ALT and AKP in emodin group were significantly decreased (P<0.05-0.01), and TP and ALB were significantly increased (P<0.05-0.01). , G decreased, but no statistical difference; (2) Morphological examination, emodin group significantly reduced hepatocyte injury. Conclusion: Emodin has a protective effect against carbon tetrachloride-induced liver injury.