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目的评价核素法乳腺癌前哨淋巴结活检术对预测腋窝淋巴结状况的准确性,探讨其检查方法及临床应用意义。方法应用99mTc-硫胶体作为示踪剂对46例临床分期为T1-2N0M0的乳腺癌患者进行前哨淋巴结活检,所有患者均同时行腋窝淋巴结清扫,统计其发现率、准确率、假阴性率、假阳性率。结果46例乳腺癌患者中,38例检出前哨淋巴结,检出率为82.61%,平均每例1.4枚(1~3枚),清扫腋窝淋巴结平均每例10.8枚(4~19枚)。用前哨淋巴结预测腋淋巴结转移的94.74%,准确率为94.74%,特异度为100%,假阴性率为5.26%。结论核素法前哨淋巴结活检术能较准确预测腋窝淋巴结转移情况,但病例的选择有一定的适应症,与术者操作经验有关。
Objective To evaluate the accuracy of the method of radionuclide sentinel lymph node biopsy in predicting the status of axillary lymph nodes in breast cancer and to explore its examination method and its clinical significance. Methods Sentinel lymph node biopsy was performed in 46 breast cancer patients with clinical stage T1-2N0M0 using 99mTc-sulfur colloids as tracer. All patients underwent axillary lymph node dissection at the same time. The detection rate, accuracy, false negative rate, false-negative rate, Positive rate. Results Of the 46 breast cancer patients, 38 sentinel lymph nodes were detected, the detection rate was 82.61%, with an average of 1.4 (1 ~ 3) cases per case. The average number of axillary lymph nodes was 10.8 (4 ~ 19). Sentinel lymph node metastasis with axillary lymph node metastasis 94.74% accuracy rate was 94.74%, specificity was 100%, false negative rate was 5.26%. Conclusions Nuclide sentinel lymph node biopsy can accurately predict axillary lymph node metastasis, but the choice of cases has some indications, and the operation experience of the surgeon.