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1.组织病理像及其分类本病特征性病理组织所见是能看到极少数的2个核、多核或单核的巨细胞(RS细胞或H细胞)伴有反应性浸润细胞(淋巴细胞、浆细胞、组织细胞、嗜酸粒细胞、中性粒细胞)及不同程度的纤维化和坏死。组织病理分类是基于Rye分类法,但其组织病理分类也在不断完善。Kiel研究组提倡根据生物学特征性将不同的几个病型分为三个亚型,其中最具特征的亚型是肉芽肿亚型,小结节状淋巴细胞优势型。他们认为这种细胞起源于滤泡中心细胞。目前认为这一组织亚型是低度恶性B细胞型非何杰金氏淋巴瘤(NHL)。在HD病程经过中,见到的NHL的发生。被认
1. Histopathology and its classification The pathological features of this disease can be seen in a very small number of 2 nuclear, multinucleated or mononuclear giant cells (RS cells or H cells) with reactive infiltrating cells (lymphocytes , Plasma cells, tissue cells, eosinophils, neutrophils) and varying degrees of fibrosis and necrosis. Histopathological classification is based on the Rye classification, but its histopathological classification is also constantly improving. Kiel’s research group advocates the classification of several different disease types into three subtypes based on their biological characteristics. The most prominent subtypes are the granuloma subtype and the nodular lymphocyte predominance. They think this kind of cells originate from follicular center cells. It is presently believed that this tissue subtype is low grade B-cell non-Hodgkin’s lymphoma (NHL). During the course of HD disease, we see the occurrence of NHL. Recognized