论文部分内容阅读
目的探讨女性癫患者月经期癫发作的特点、原因及治疗经验。方法回顾性分析2007—2012年我科收治的37例月经期癫发作的病例。结果女性癫患者月经期癫发作加重的主要表现为癫的发作频率的增加,月经期癫发作加重与女性月经期体内的雌激素及孕激素水平、大脑皮质和海马神经细胞内雌激素及孕激素受体水平以及女性月经期AEDs药物清除能力增强等因素有关。结论增加AEDs的用药次数、用量或联合用药治疗女性癫患者月经期癫发作安全有效。
Objective To investigate the characteristics, causes and treatment experience of menstrual epilepsy in women with epilepsy. Methods Retrospective analysis of 37 cases of menstrual seizures in our department from 2007 to 2012 were retrospectively analyzed. Results The main manifestations of menstrual epilepsy in women with epilepsy were increased seizure frequency, increased menstrual epilepsy and estrogen and progesterone levels in women during menstrual period, estrogen and progesterone levels in female cortex and hippocampal neurons Hormones and progesterone receptor levels and female menstrual AEDs drug clearance and other factors. Conclusions It is safe and effective to increase the frequency, dosage or combination of AEDs for the treatment of menstrual epilepsy in women with epilepsy.