论文部分内容阅读
目的:探讨安替可胶囊联合冷循环射频消融(CRFA)治疗原发性肝癌的疗效。方法:将528例原发性肝癌患者随机分为两组,治疗组和对照组各264例。在超声引导下,采用单针和集束针进行CRFA治疗。其中单针采用穿刺探头引导,集束针采用三点一线定位法、分散患者注意力法以及二步进针法准确刺入肿块内。肿块内血供丰富的部位是CRFA治疗的重点,合理的布针及消融是治疗本病的关键。<3cm的肿块采用单针治疗,3~5cm的肿块采用集束针治疗,>5cm的肿块需采用集束针进行多次消融治疗,并根据肿块形状、部位及周围组织器官情况进行合理的布针;治疗组在此基础上口服安替可胶囊治疗,每次2粒,每日3次。结果:治疗组有效率为95.0%,对照组为50.0%,两组有效率比较有显著性差异(P<0.05);两组生活质量比较,治疗组显著优于对照组(P<0.05)。治疗组AFP、AFU、CEA三种肿瘤标志物水平的降低程度明显优于对照组,两组比较差异显著(P<0.05)。结论:安替可胶囊联合CRFA是一种安全有效的治疗肝细胞肝癌的方法,其疗效主要取决于针型的选择、布针方法以及消融的范围,该法值得临床推广应用。
Objective: To investigate the curative effect of Antipyrrole combined with cold cycle radiofrequency ablation (CRFA) in the treatment of primary liver cancer. Methods: 528 cases of primary liver cancer were randomly divided into two groups, the treatment group and the control group of 264 cases. Under ultrasound guidance, CRFA was treated with single and bundle needles. Among them, the single-needle is guided by the puncture probe, the three-line positioning method of the cluster needle, the distraction method and the two-step needle method accurately penetrate the tumor. The mass of blood supply in the tumor is the focus of CRFA treatment. Reasonable needle and ablation is the key to the treatment of this disease. <3cm lumps with a single needle treatment, 3 ~ 5cm lumps treated with bundles of needles,> 5cm lumps need to be used multiple ablation treatment, and according to the shape of the lumps, parts and the surrounding tissue and organs of reasonable cloth; On the basis of this treatment, the treatment group was treated with Antipyrine capsules, 2 capsules each time, 3 times a day. Results: The effective rate was 95.0% in the treatment group and 50.0% in the control group, and the effective rate was significantly different between the two groups (P <0.05). The quality of life of the two groups was significantly better than that of the control group (P <0.05). The levels of AFP, AFU and CEA in the treatment group were significantly lower than those in the control group, with significant difference between the two groups (P <0.05). CONCLUSION: Anti-capsule and CRFA is a safe and effective method for the treatment of hepatocellular carcinoma. The curative effect depends mainly on the selection of acupoints, the method of needle distribution and the scope of ablation. This method is worthy of clinical application.