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治疗感染性疾病而投用的抗菌药物,在达到临床疗效的血药浓度时,对机体免疫功能很少发生抑制作用,故不必为此而担忧。但是,在体外试验中,较高浓度的抗菌药物,如四环类、氨基糖苷类、大环内酯类抗生素和利福平等,对吞噬细胞的功能等机体防御系统有抑制作用,为此,本文概述抗菌药物的免疫抑制作用。尤其在治疗免疫抑制患者时更应考虑抗菌药物的免疫抑制作用。在抗菌药物中,以抑制蛋白合成为其主要作用机理者,当其大量投用时可抑制嗜中性白细胞的功能和抗体的产生。虽然上述的
Antimicrobial agents that are administered to treat infectious diseases rarely have an inhibitory effect on the immune function of the body when they reach the plasma concentration of clinical efficacy. Therefore, it is not necessary to worry about this. However, in vitro tests, higher concentrations of antibacterial drugs, such as tetracyclines, aminoglycosides, macrolides and rifampicin, have an inhibitory effect on the body’s defensive system, such as the function of phagocytes. To this end, This article outlines the immunosuppressive effects of antibacterials. Especially in the treatment of immunosuppressed patients should consider the antimicrobial immunosuppressive effect. Antibacterial drugs to inhibit protein synthesis as its main mechanism of action, when it is administered in large quantities can inhibit neutrophil function and antibody production. Although the above