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目的 了解过敏性紫癜儿童的临床特征。方法 回顾性分析过敏性紫癜患儿 184例 ,对其临床表现及特征进行分析。结果 ①发病年龄均 >2岁 ,平均发病年龄 (7.8± 2 .6 )岁 ;6 7.4 %患儿于秋冬季节发病 ;6 2 .5 %患儿有明确诱因 ,以上呼吸道感染为主。②所有病人均有典型皮肤紫癜 ,分布于下肢 (10 0 % )、臀部(47.3% )、上肢 (17.4 % )等。 89.1%患儿以皮肤紫癜首发 ,少数以胃肠道及关节症状为首发症状后 2周内出疹 ,先出现肾脏损害而后出疹者罕见。胃肠道及关节症状发生率分别为 6 0 .9%和 4 4 .6 %。紫癜性肾炎发生率为 5 2 .2 % ,临床上主要表现为血尿和 (或 )蛋白尿 (6 8.8% ) ,病理改变主要为Ⅰ~Ⅲ级 (85 .2 % )。③ 4 4 .0 %病人血沉增快 ,2 4 .1%ASO增高 ;6 3.7%病人IgA增高 ,IgG ,IgM及补体绝大多数正常。 结论 过敏性紫癜为儿童常见病 ,且有其本身临床特征及发病规律
Objective To understand the clinical features of children with allergic purpura. Methods Retrospective analysis of 184 cases of children with Henoch-Schonlein purpura, clinical manifestations and characteristics were analyzed. Results ① The age of onset was> 2 years, with an average age of onset of (7.8 ± 2. 6) years; 6 of 7.4% of children were diagnosed as fall and winter seasons; 62.5% of children had definite causes, mainly respiratory infections. ② All patients have a typical skin purpura, located in the lower extremities (10 0%), buttocks (47.3%), upper extremities (17.4%) and so on. 89.1% of children with purpura first episode of skin, a small number of gastrointestinal and joint symptoms as the first symptom within 2 weeks after the first rash, kidney damage and rash were rare. Gastrointestinal and joint symptoms were 60.9% and 44.6%, respectively. The incidence of purpura nephritis was 52.2%. The main clinical manifestations were hematuria and / or proteinuria (68.8%). The main pathological changes were grade Ⅰ-Ⅲ (85.2%). ③ 43.0% patients ESR faster, 24.1% ASO increased; 6 3.7% IgA patients increased, IgG, IgM and most of the normal complement. Conclusion Anaphylactoid purpura is a common disease in children, and has its own clinical features and pathogenesis