论文部分内容阅读
结核病是一种慢性病,在较长的病程中发生其它疾病的机会亦较多。因此,在临床上经常遇到结核病患者需要同时治疗其它疾病这一课题。在抗结核治疗中也常常需要联合用药。但是,有些抗结核药与某些药物合用时可发生药效降低甚至拮抗作用,或者副作用加重甚至产生其它并发症。现就此问题作一简述,以引起注意。一、异烟肼1.维生素 B_6能够防治异烟肼所引起的神经系统毒性反应和其它毒性副作用已为众所周知,但此二药合用是否会导致异烟肼的疗效降低则尚有争论。一般认为,吡哆醛、丙酮酸是细菌代谢中所必需的物质,异烟肼正是通过与体内的吡哆醛、丙酮酸等结合形成腙,使结核菌不能利用,影响它们的代谢而发挥抗结
Tuberculosis is a chronic disease, and there are more opportunities for other diseases in the longer course of the disease. Therefore, in clinical practice, TB patients often need to treat other diseases at the same time. In the anti-TB treatment also often need combination therapy. However, some antituberculosis drugs may reduce or even antagonize the effects of certain drugs, or may cause side effects and even other complications. This issue is now briefly outlined to draw attention. Isoniazid 1. Vitamin B_6 is able to prevent isoniazid caused by nervous system toxicity and other toxic side effects have been well-known, but the combination of these two drugs will lead to a decrease in the efficacy of isoniazid is still controversial. It is generally believed that pyridoxal and pyruvate are essential substances in bacterial metabolism. It is through the combination of isopyrazol and pyruvic acid with isoniazid to form hydrazones so that tuberculin can not be utilized and affect their metabolism Anti-knot