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为了解青心酮对慢性阻塞性肺病（慢阻肺）患者血流动力学的影响，用右心漂浮导管检测了１１例慢阻肺患者应用青心酮前、后血流动力学某些参数，同时采用放射免疫分析法测定了血浆心钠素及环磷酸苷类水平。结果：静脉注射青心酮后，肺动脉平均压及肺循环阻力、体循环阻力均下降（Ｐ＜０．０５）．体动脉压及动脉血气指标无明显变化（Ｐ＞０．０５），心输出量在正常范围内增加。血浆心钠素、环磷酸鸟苷水平下降（Ｐ＜０．０１，Ｐ＜０．０５）。表明青心酮可能通过调节环磷酸腺苷、环磷酸鸟苷的比值而达到扩血管目的，其心钠素降低可能是一种继发性反应。
To understand the effect of Qingxin Ketone on hemodynamics in patients with chronic obstructive pulmonary disease (COPD), we used right heart floating catheter to detect the hemodynamic parameters of hemodynamics before and after administration of Qingxin ketone in 11 patients with chronic obstructive pulmonary disease. At the same time, plasma atrial natriuretic peptide and cyclic phosphoglycoside levels were measured by radioimmunoassay. RESULTS: After intravenous injection of Qingxin ketone, the mean pulmonary arterial pressure, pulmonary circulation resistance, and body circulation resistance all decreased (P<0.05). There was no significant change in arterial blood pressure and arterial blood gas index (P>0.05), and cardiac output increased within the normal range. Plasma atrial natriuretic peptide and cyclic guanosine monophosphate levels decreased (P<0.01, P<0.05). It was shown that Qingxin Ketone could achieve the goal of vasodilatation by regulating the ratio of cyclic adenosine monophosphate and cyclic guanosine monophosphate. The reduction of atrial natriuretic peptide may be a secondary response.