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胃黏膜功能是胃功能状态的指征。胃黏膜的病理过程是从慢性浅表病变到胃黏膜的溃疡,进而萎缩性改变,最后是胃癌的发生。萎缩性胃炎可通过手术治疗减少恶变为胃癌的可能,因此胃黏膜病变的筛查十分重要。血清胃蛋白酶原(PG)检测是一种简单易行、费用低、敏感度和特异度高的方法,近年来受到国内外学者的高度重视。研究表明胃黏膜功能与PG有生物学的联系,因此通过PG的血清学实验可对慢性萎缩性胃炎进行“活检”。
Gastric mucosal function is an indication of gastric status. The pathological process of gastric mucosa is from chronic superficial lesions to gastric ulcer, and then atrophic changes, and finally the occurrence of gastric cancer. Atrophic gastritis can be surgically treated to reduce the possibility of malignant transformation to gastric cancer, so the screening of gastric mucosal lesions is very important. Detection of serum pepsinogen (PG) is a simple, low-cost, high sensitivity and high specificity method, which has been highly valued by scholars at home and abroad in recent years. Studies have shown that gastric mucosal function is biologically related to PG, so that “biopsy” of chronic atrophic gastritis can be performed by PG serological tests.