作者简述子孢子产生保护性免疫的历史,重点介绍环子孢子蛋白(circumspo-rozoite proteins(CSP))在子孢子疫苗发展前景中的作用。所有成熟而有感染性的涎腺内子孢子的外膜都被酸性的30—60KDa多肽覆盖,此多肽被称为环子孢子蛋白(CSP)。CSP的单克隆抗体及其抗体结合片段(Fab),在体内和体外可中和子孢子的感染性及阻止子孢子附着和进入靶细胞。在按蚊中肠的卵囊内未成熟子孢子,其外膜上具有少量的或没有CSP,他们无感染性。在子孢子感染性和子孢子外膜上出现 The authors outline the history of sporozoites producing protective immunity and highlight the role of circumspo-rozoite proteins (CSPs) in the development of sporozoite vaccines. The outer membrane of all mature and infectious salivary gland sporozoites is covered by an acidic 30-60 kDa polypeptide called the circumsporozoite protein (CSP). CSP monoclonal antibodies and their antibody-binding fragments (Fabs) neutralize the infectivity of sporozoites in vivo and in vitro and prevent sporozoite attachment and entry into target cells. Immature sporozoites in the anophoroid midgut oocysts, with little or no CSP on their outer membranes, are non-infectious. Occurrence in sporozoites and sporozoites