论文部分内容阅读
目的 :观察 p16蛋白在胃癌中的表达规律及其与预后的关系。方法 :应用免疫组织化学 S- P法 ,对6 2例有随访结果的胃癌组织进行 p16蛋白检测。结果 :有淋巴结转移组 p16蛋白阳性率 18.9%显著低于无淋巴结转移组 48.0 % (P<0 .0 5 ) ;p16蛋白阳性组胃癌患者术后 5年生存率 31.6 % (6 / 19)显著高于 p16蛋白阴性组9.3% (4 / 43) (P<0 .0 5 )。结论 :p16蛋白表达状况可作为临床判断胃癌生物学行为、转移潜能及患者预后的一项重要指标。
Objective: To observe the expression of p16 protein in gastric carcinoma and its relationship with prognosis. METHODS: The p16 protein was detected in 62 gastric cancer tissues with follow-up results by immunohistochemical S-P method. RESULTS: The positive rate of p16 protein in lymph node metastasis group was 18.9%, which was significantly lower than that of no lymph node metastasis group (48.0 %, P<0.05). The postoperative 5-year survival rate of p16 protein positive gastric carcinoma group was 31.6% (6/19) significant. It was 9.3% (4/43) higher than the p16 protein negative group (P<0.05). Conclusion : The expression of p16 protein can be used as an important index for clinical judgment of biological behavior, metastatic potential and prognosis of gastric cancer.