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1986年9月28日,一位40岁、既往健康的男性工人在用聚氨酯聚合物涂织物的某工厂实验室工作不到2周便发生腹痛、恶心,离开工作环境后症状即缓解。发病时天冬氨酸转氨酶(AST)水平高达949 U//L(正常值≤35U/L)。两个月后,其丙氨酸转氨酶(ALT)水平仍高达207 U/L(正常值≤32 U/L),AST为49 U/L。一个月内,另有三位同事出现同样症状和肝功能异常。对工作环境的调查发现这些工人在通风不良条件下大量使用二甲基甲酰胺(DMF)。DMF是丙烯酸
On September 28, 1986, a 40-year-old, formerly healthy male worker developed abdominal pain and nausea after working in a factory laboratory with a polyurethane-coated fabric for less than two weeks. The symptoms were relieved after leaving the work environment. The onset of aspartate aminotransferase (AST) levels up to 949 U // L (normal ≤ 35U / L). Two months later, the alanine aminotransferase (ALT) level was still as high as 207 U / L (normal ≤ 32 U / L), AST was 49 U / L. Within a month, three other colleagues showed the same symptoms and abnormal liver function. Surveys on the working environment found that these workers used DMF extensively in poorly ventilated conditions. DMF is acrylic acid