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目的为探讨高原地区高血压患者在平原地区血尿酸的含量,了解高原地区高血压患者血压升高与血尿酸的关系。方法选择于2007年1月至2010年1月在我院内科住院治疗的患者中符合高血压诊断标准者(WHO)134例作为观察组,选择同期来我院体检的世居或移居西藏高原地区的健康者113例作为对照组。所有受检者均空腹12小时以上,于清晨抽取静脉血2～3 mL,送生化室于当天检查观察指标。结果高血压组血尿酸水平显著高于对照组差异具有极显著性(P<0.001),高血压病1级、2级、3级各组血尿酸水平均显著高于对照组(P均<0.05),高血压病1级患者血尿酸水平均显著低于高血压病2级、3级(P<0.001、P<0.05),高血压病2级、3级患者血尿酸水平相近,差异无显著性(P>0.05)。两组性别、民族之间的比较结果显示,两组男性血尿酸水平均显著高于女性(P分别<0.05、P<0.001),民族之间的比较结果显示两组汉族血尿酸水平均显著高于藏族(P均<0.05)。结论血尿酸的增高即是高血压病产生的原因之一,也是高血压病患者代谢紊乱的结果之一,产生的原因主要是与血尿酸生成增加和排出减少有关。高血压病和健康对照组男性血尿酸水平均高于女性,汉族级高于藏族。分析认为改善生活方式和饮食习惯,平衡持久的降压治疗对改善体内代谢,降低血尿酸水平是有益的。
Objective To investigate the content of serum uric acid in the plain area of high blood pressure patients in the plateau area and to investigate the relationship between blood pressure and serum uric acid in patients with hypertension in the plateau area. Methods From January 2007 to January 2010 in our hospital inpatient treatment of patients with hypertension diagnostic criteria (WHO) 134 cases as the observation group, choose the same period to our hospital physical examination or living in the Tibetan Plateau region 113 healthy people as control group. All subjects were fasting for more than 12 hours in the early morning venous blood drawn 2 ~ 3 mL, sent to the biochemical room on the day of inspection indicators. Results The level of serum uric acid in hypertension group was significantly higher than that in control group (P <0.001). The levels of serum uric acid in grade 1, 2 and 3 of hypertension group were significantly higher than those in control group (all P <0.05 ), Blood uric acid levels in patients with grade 1 hypertension were significantly lower than those in patients with hypertension 2 and 3 (P <0.001, P <0.05), and blood uric acid levels in patients with hypertension 2 and patients 3 were similar (P> 0.05). Comparison of gender and ethnicity between the two groups showed that serum uric acid levels were significantly higher in both groups than in females (P <0.05, P <0.001, respectively). Comparisons among ethnic groups showed that serum uric acid levels were significantly higher in both groups In Tibetan (all P <0.05). Conclusion The increase of serum uric acid is one of the causes of hypertension. It is also one of the outcomes of metabolic disorders in patients with hypertension. The reasons are mainly related to the increase of blood uric acid and the decrease of excretion. Hypertension and healthy control group, male blood uric acid levels were higher than the female, Han-level higher than the Tibetan. Analysis suggests that improving lifestyle and eating habits, balanced long-lasting antihypertensive treatment to improve the body’s metabolism, lower blood uric acid levels are beneficial.