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肝硬化腹水发生机制颇为复杂,而顽固性腹水突出表现为有效血容量不足,导致肾血流量严重降低,使钠水排出更加困难.应用多巴胺(1～5μg/kg·min~(-1)可使肾血流量及排钠量增加.本研究目的是观察应用多巴胺和利尿剂治疗肝硬化顽固性腹水的疗效及电解质肾功能变化.1 材料与方法1.1 病例选择:随机选择住院肝硬化顽固性腹水患者50例,均符合Raju对顽固性腹水的判定标准.并发肝癌、腹水感染或1个月内有出血及肝性脑病者均排除在外.1.2 研究方法:随机分为2组.观察组(多巴胺组):多巴胺40mg和速尿60mg入5%葡萄糖100
Cirrhosis of the ascites mechanism is quite complex, and refractory ascites prominence of insufficient hypovolemia, resulting in severe renal blood flow decreased, so that sodium water is more difficult to discharge.Using dopamine (1 ~ 5μg / kg · min ~ (-1) Can make the renal blood flow and the amount of sodium increased.The purpose of this study is to observe the application of dopamine and diuretics in the treatment of refractory cirrhosis of the ascites and electrolyte changes in renal function.1 Materials and Methods 1.1 Case Selection Randomized hospitalized cirrhosis refractory 50 cases of patients with ascites, are in line with the determination of refractory ascites Raju criteria. Concurrent hepatocellular carcinoma, ascites infection or within 1 month of hemorrhage and hepatic encephalopathy were excluded.1.2 Methods: Randomly divided into two groups.Observation group Dopamine group): dopamine 40 mg and furosemide 60 mg into 5% glucose 100