论文部分内容阅读
世界卫生组织(WHO)建立药品不良反应数据库的主要功能之一就是发现信号(signal)。WHO对信号的定义:是指药物与不良事件之间可能存在的因果关系的信息。这种因果关系是未知的或未被完全证明的。乌普萨拉中心作为WHO药品不良反应监测的专业技术机构,经常组织专家对其数据库中产生的信号进行评估。该数据库使用贝叶斯可信神经网络分析方法(BCPNN methodology),IC值(Information Component)是基于该方法产生的数据依赖性强度信号值,用来表示药品与不良事件之间存在的因果关系强度。本文是David Clark博士根据IC值对西布曲明与健忘症之间因果关系进行分析的一篇文章。
One of the main functions of the World Health Organization (WHO) in establishing a database of ADRs is to find the signal. WHO definition of signal: refers to the possible causal relationship between drugs and adverse events. This causal relationship is unknown or not fully proved. Uppsala Center, WHO’s expert body for monitoring adverse drug reactions, often organizes experts to evaluate the signals generated in its database. This database uses the BCPNN methodology, which is based on the data-dependent intensity signal values generated by this method and is used to indicate the strength of the causal relationship between the drug and the adverse event . This article is based on an analysis of the causal relationship between sibutramine and amnesia by Dr. David Clark based on IC values.