现已发现十余种凝固酶阴性葡萄球菌(CNS),其中大部分为条件致病菌,但对其致病机理仍不清楚。Penny和Bayston(1972)首先报道一株从脑脊液中分离到的表皮葡萄球菌能够产生粘液性物质(Slime,简称粘质),能粘附在试管内壁,并据此将CNS分为产粘质和不产粘质两大类。这种粘质的化学成份目前还不十分清楚。它能促使CNS对光滑表面的粘附,抵抗不利因素,逃避宿主的防御,起到自身保护的作用,从而增加对宿主感染的机会。Christensen认为粘质既可能是一种定居因子,也可能是一 More than a dozen coagulase-negative staphylococci (CNS) have been found, most of which are opportunistic pathogens, but their pathogenic mechanism remains unclear. Penny and Bayston (1972) first reported that a Staphylococcus epidermidis isolated from cerebrospinal fluid could produce slime (slime), which can adhere to the inner wall of the test tube, Not produce two major categories of mucilage. The chemical composition of this sticky substance is not yet clear. It can promote the adhesion of CNS to the smooth surface, resist unfavorable factors, evade the defense of the host and play the role of self-protection, thereby increasing the chance of host infection. Christensen thinks that mucilage may be either a settlement factor or a one