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心钠素(ANF)是一种多肽类激素,对机体许多生理过程起着重要的调节作用。本文采用利血平所致脾虚小鼠模型,发现其血浆ANF水平较正常显著降低(P<0.001),而脾组织ANF水平升高显著(P<0.001),加味四君子汤对这种变化有明显的纠正作用,提示ANF与脾虚发病机理和加味四君子汤药理作用机理有一定关系。实验还表明,加味四君子汤使脾虚小鼠一般情况改善,并对脾虚模型小鼠体重及胸腺、脾脏、睾丸和子宫的湿重减轻有显著的保护作用。
Atrial natriuretic peptide (ANF) is a peptide hormone that plays an important regulatory role in many physiological processes in the body. The reserpine-induced spleen-deficient mouse model found that plasma ANF levels were significantly lower than normal (P<0.001), while spleen tissue ANF levels were significantly elevated (P<0.001). Modified Sijunzi Decoction has a significant effect on this change. The corrective action suggested that ANF has a certain relationship with the pathogenesis of spleen deficiency and the pharmacological mechanism of Jiawei Sijunzi decoction. Experiments also showed that Modified Sijunzi Decoction improved the general condition of mice with spleen deficiency, and had a significant protective effect on the body weight of mice with spleen deficiency and the reduction of wet weight of thymus, spleen, testis, and uterus.