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目的 探讨一氧化氮等自由基与煤工尘肺发生发展的关系。方法 系统测定 16 3例不同期别煤工尘肺患者(0 + →Ⅰ→Ⅱ→Ⅲ )及 40例健康对照者血清一氧化氮 (NO)、过氧化脂质 (LPO)、总巯基 (T SH)含量及超氧化物歧化酶同功酶 (SODs)活性。结果 与对照组相比 ,各期别煤工尘肺机体血清NO含量、LPO水平均显著升高 ,而总巯基含量则显著下降 ,血清总SOD活性亦呈代偿性增加 ,且表现为MnSOD活性的显著增加。结论 煤工尘肺发生过程中体内一氧化氮及氧自由基反应呈病理性加剧 ,氧化 /抗氧化状态严重失衡。
Objective To investigate the relationship between free radicals such as nitric oxide and the occurrence and development of pneumoconiosis in coal workers. Methods Serum nitric oxide (NO), lipid peroxidation (LPO), total sulfhydryl group (T SH) in 16 3 coal miners with pneumoconiosis (0 + → Ⅰ → Ⅱ → Ⅲ) and 40 healthy controls ) Content and superoxide dismutase isozyme (SODs) activity. Results Compared with the control group, the levels of NO and LPO in coal pneumoconiosis were significantly increased, but the content of total sulfhydryl group was significantly decreased and the total serum SOD activity also showed a compensatory increase, and the activity of MnSOD A significant increase. Conclusion During the course of coal workers’ pneumoconiosis, the reaction of nitric oxide and oxygen free radicals in the body showed pathological exacerbation, and the state of oxidation / antioxidation was seriously unbalanced.