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目的了解血清肝纤维化指标与临床及病理的关系。方法对１９０例各种肝炎患者血清进行透明质酸酶（ＨＡ）、板层素（ＬＮ）、ＩＮ型胶原（ＩＶ－Ｃ）、Ⅲ型前胶原（ＰＣⅢ）测定，部分病例进行肝活检。结果血清 ＨＡ、ＬＮ、ＩＶ－Ｃ、ＰＣⅢ水平随着肝炎疾病程度的加重而升高。 ＨＡ、ＬＮ、ＩＶ－Ｃ、ＰＣⅢ在病理不同阶段变化不同。结论肝纤维化指标可用于慢性肝炎病情严重程度的判断，且ＨＡ、ＬＮ较早反映炎症活动度，而 ＰＣⅢ则较早反映纤维化程度。
Objective To understand the relationship between serum levels of hepatic fibrosis and clinical and pathological features. Methods Serum samples from 190 patients with hepatitis were assayed for hyaluronidase (HA), laminin (LN), collagen IV (IV-C), and procollagen III (PCIII). Liver biopsy was performed in some cases. Results Serum levels of HA, LN, IV-C and PCⅢ increased with the severity of hepatitis. HA, LN, IV-C, PCⅢ in different stages of pathological changes. Conclusion The indexes of liver fibrosis can be used to judge the severity of chronic hepatitis. HA and LN reflect the activity of inflammation earlier, while PC Ⅲ reflects the degree of fibrosis earlier.