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目的 :探讨粒 巨噬细胞集落刺激因子 (rhGM CSF)在合并真菌感染的恶性血液病中与抗真菌药物联合应用的地位。方法 :对合并真菌感染的恶性血液病人在大扶康治疗同时 ,随机分成加rhGM—CSF(2— 5 μg/kg)和不加rhGM CSF两组。结果 :接受大扶康加rhGM CSF治疗的患者有效率为 88 0 % ,对照组为 6 9 6 % (P <0 0 5 )。中性粒细胞恢复程度及真菌清除时间 ,实验组与对照组均有显著差异 (P <0 0 5 ,0 0 1)。结论 :rhGM CSF加可速中性粒细胞恢复 ,缩短真菌清除时间 ,与抗真菌药物协同可提高其抗菌疗效
Objective: To investigate the role of rhGM CSF in combination with antifungal agents in the treatment of hematologic malignancies complicated with fungal infection. Methods: Malignant hematologic patients with fungal infection were randomly divided into two groups: rhGM-CSF (2-5 μg / kg) and rhGM-CSF without treatment. Results: The effective rate was 88% in patients receiving rhodamine plus rhGM CSF and 69.6% in the control group (P <0.05). Neutrophil recovery and fungal clearance time, the experimental group and the control group were significantly different (P <0 05, 001). Conclusion: rhGM CSF plus can speed neutrophil recovery, shorten the fungal clearance time, and anti-fungal drugs can increase its antimicrobial efficacy