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~(125)Ⅰ标记尖吻蝮蛇毒凝血样酶,放化纯95.5％和比放射性188.7 MBq/mg。 兔iv ~(125)Ⅰ-TLE后,血放射性—时间曲线符合二室模型,算出药物动力学参数。组织分布以肾、胆、肝的放射性最高。
~ (125) Ⅰ labeled Agkistrodon viperine thrombolytic enzyme, 95.5% radiochemical purity and 188.7 MBq / mg radioactivity. Rabbit iv ~ (125) Ⅰ-TLE, the blood radioactivity - time curve in line with the two-compartment model to calculate the pharmacokinetic parameters. Tissue distribution of kidney, gallbladder, liver radioactive highest.