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目的 :了解白细胞介素 1β(IL 1β)在癫痫发作中的作用。 方法 :采用记录脑电图 (EEG)同时观察行为的方法 ,观察IL 1β和IL 1受体拮抗剂 (IL 1ra)侧脑室注射对戊四氮 (PTZ)致痫大鼠行为和皮层、海马EEG的影响。结果 :IL 1β能明显缩短PTZ致大鼠急性惊厥发作及痫波发放的潜伏期 ,增加痫波的发放频率。IL 1ra能减少急性惊厥痫波发放频率 ,对急性惊厥发作及痫波发放的潜伏期和惊厥发作强度无明显影响。但IL 1ra能显著延长大鼠点燃后PTZ诱导的惊厥发作和痫波发放的潜伏期 ,减轻惊厥发作强度。结论 :内源性IL 1β是促进癫痫发作的因素之一 ,可能在癫痫慢性发展中提高大脑神经元的兴奋性中起着重要作用。
AIM: To understand the role of interleukin-1β (IL-1β) in seizures. Methods: EEG was used to observe the behavior at the same time. The effects of IL 1β and IL 1 receptor antagonist (IL 1ra) injected into the lateral ventricle on the behavior and cortex, hippocampal EEG Impact. Results: IL 1β significantly shortened the latency of PTZ-induced acute convulsions and the release of epileptic rats, and increased the frequency of epileptic waves. IL 1ra can reduce the frequency of epileptic seizures in acute seizures, and has no significant effect on the latency of seizures and the intensity of seizures. IL 1ra, however, significantly prolonged PTZ-induced seizures and the release of epileptic waves and reduced the intensity of seizures in rats. Conclusion: Endogenous IL-1β is one of the factors that promote seizures and may play an important role in increasing the excitability of cerebral neurons during the chronic development of epilepsy.