目的探讨盐酸阿扎司琼在预防化疗所致恶心呕吐中的作用。方法 84例恶性肿瘤患者随机分为试验组和对照组,每组各42例。试验组患者化疗前静脉注射国产盐酸阿扎司琼10mg∶100ml,每天1次。对照组患者采用进口盐酸昂丹司琼8mg,化疗前静注,每天1次。评价2组患者治疗期间恶心发生情况、止吐疗效、初次呕吐发生时间、不良反应发生情况。结果试验组预防恶心发生有效率(61.9%)高于对照组(54.8%),试验组完全缓解率(81.0%)明显高于对照组(61.9%),差异有统计学意义(P<0.05),试验组初次呕吐发生时间明显高于对照组(P<0.05),不良反应发生情况两组无差异。结论国产盐酸阿扎司琼对预防化疗所致恶心呕吐有效、安全,值得临床推广。 Objective To investigate the role of azasetron hydrochloride in the prevention of chemotherapy-induced nausea and vomiting. Methods 84 patients with malignant tumor were randomly divided into experimental group and control group, 42 cases in each group. Patients in the experimental group received intravenous injection of domestic-made azasetron hydrochloride 10 mg: 100 ml once a day before chemotherapy. The control group of patients with imported ondansetron hydrochloride 8mg, intravenous chemotherapy, once daily. Evaluation of 2 groups of patients during treatment nausea, antiemetic efficacy, initial vomiting, adverse reactions occurred. Results The effective rate of nausea (61.9%) in experimental group was significantly higher than that in control group (54.8%), and the complete remission rate (81.0%) in experimental group was significantly higher than that in control group (61.9%) (P <0.05) , The initial vomiting time in the experimental group was significantly higher than that in the control group (P <0.05), and the incidence of adverse reactions was no difference between the two groups. Conclusion Domestic made on the stability of nausea and vomiting caused by chemotherapy is safe and worthy of clinical promotion.