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目的分析小儿病毒性脑炎(VE)预后的影响因素,为小儿VE诊治方案和预后评估提供参考。方法选择2015年10月-2016年10月浙江省台州医院收治的88例重症VE患儿作为研究对象,根据预后情况分为预后良好组50例和预后不良组38例,采用Logistic回归分析影响重症VE患儿预后的影响因素。结果预后良好组惊厥时间、惊厥发生率、发热时间、意识障碍时间、头颅磁共振成像(MRI)异常发生率和脑电图(EEG)异常发生率均低于预后不良组;格拉斯哥预后评分(GOS)高于预后不良组(P<0.05);两组患儿年龄、性别、住院时间、脑脊液(CSF)蛋白量、CSF白细胞计数以及发热、意识障碍、低钾血症、低钠血症发生率比较,差异无统计学意义(P>0.05)。Logistic回归分析显示,惊厥时间、发热时间、意识障碍时间、GOS评分、头颅MRI异常和EEG异常是影响重症VE患儿预后的危险因素(P<0.05)。结论惊厥时间、发热时间、意识障碍时间、头颅MRI异常和EEG异常是影响重症VE患儿预后的重要危险因素,应给予足够的重视,以改善VE患儿的预后。
Objective To analyze the influencing factors of the prognosis of pediatric viral encephalitis (VE) and provide a reference for the diagnosis and treatment of VE in children. Methods Eighty-eight patients with severe VE admitted to Taizhou Hospital of Zhejiang Province from October 2015 to October 2016 were divided into two groups according to their prognosis: 50 patients with good prognosis and 38 patients with poor prognosis. Logistic regression analysis was used to analyze the influence of severe VE Factors influencing the prognosis of children with VE. Results The patients with good prognosis had significantly lower incidence of seizure, convulsions, fever, disturbance of consciousness time, frequency of MRI abnormalities and EEG abnormalities than those with poor prognosis. Glasgow Outcomes Scale (GOS) ) Were higher than those in the poor prognosis group (P <0.05). The age, gender, length of hospital stay, cerebrospinal fluid (CSF) protein, CSF white blood cell count and incidence of fever, disturbance of consciousness, hypokalemia and hyponatremia The difference was not statistically significant (P> 0.05). Logistic regression analysis showed that seizure time, fever time, disturbance of consciousness time, GOS score, cranial MRI abnormality and EEG abnormality were the risk factors influencing the prognosis of severe VE children (P <0.05). Conclusions Convulsive time, fever time, disturbance of consciousness time, cranial MRI abnormality and EEG abnormality are important risk factors affecting the prognosis of severe VE. More attention should be paid to improve the prognosis of VE.