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闭经溢乳是高泌乳素血症的典型症状。文献报道,20～30%无主诉的继发闭经和1/3的闭经溢乳病人,系泌乳素瘤引起。随着泌乳素(PRL)放射免疫测定技术及经蝶显微手术切除垂体肿瘤的开展,新药溴隐亭的应用,有关高泌乳素血症的研究,不断有新的报道。Batrinos 指出,由于 PRL 放免测定技术的发展,报道垂体肿瘤发生串显著增加。目前 CT 扫描已能发现常规 X 线摄片无法诊断的微小肿瘤。高泌乳素血症的临床表现,主要与 PRL 过高,干扰了性腺功能有关。由于促性腺激素释放激素(GnRH)抑制程度不同,可表现为各种内分泌功能紊乱,开始为黄体不健、无排卵周期、月经稀发和闭经,
Amenorrhea is a typical symptom of hyperprolactinemia. According to reports in the literature, 20 to 30% of uninformed secondary amenorrhea and 1/3 of patients with amenorrhea were caused by prolactinoma. With the development of prolactin (PRL) radioimmunoassay and transsphenoidal microsurgical resection of pituitary tumors, the application of the new drug bromocriptine, and the study of hyperprolactinemia, there have been new reports. Batrinos pointed out that due to the development of PRL radioimmunoassay techniques, there has been a report of a significant increase in pituitary tumors. CT scans have been able to detect tiny tumors that cannot be diagnosed with conventional X-rays. The clinical manifestations of hyperprolactinemia are mainly related to high PRL and interfere with gonadal function. Due to the different degree of inhibition of gonadotropin-releasing hormone (GnRH), various endocrine disorders can be manifested. They begin with a poorly corpus luteum, aperiodic cycle, menstrual sparseness, and amenorrhea.