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目的就制霉菌素甘油联合碳酸氢钠预防口腔霉菌感染进行探讨。方法选取2011年10月至2013年10月我院收治的94例慢性阻塞性肺疾病急性加重期(AECOPD)患者,将其随机分为两组,均在祛痰、抗感染治疗的基础上,采用布地奈德进行雾化吸入后,对照组采用10~20 ml温开水,同时漱口1~2 min;观察组采用碳酸氢钠溶液漱口,同时将舌面和口腔黏膜涂抹上制霉菌素甘油,一日内禁饮、禁食。治疗1个疗程后,对两组患者的咽拭子霉菌涂片阳性例数进行观察。结果观察组患者中有2例(3.85%)呈现出阳性,对照组患者中有9例(21.43%)呈现出阳性。两组阳性率具有较为明显的差异,有统计学意义(P<0.01)。结论 AECOPD患者若采用布地奈德雾化吸入治疗,则必须要加强期口腔护理,涂搽制霉菌素甘油及4%碳酸氢钠溶液漱口,药物费用低、用量少,能有效降低患者的痛苦,可达到有效预防口腔霉菌感染的效果。
Objective To investigate the effect of nystatin and sodium bicarbonate on prevention of oral mold infection. Methods A total of 94 AECOPD patients admitted to our hospital from October 2011 to October 2013 were randomly divided into two groups. On the basis of expectorant and anti-infective therapy, After inhalation with budesonide, the control group was treated with 10 ~ 20 ml warm water and mouthwash for 1 ~ 2 min. The observation group was given sodium bicarbonate solution for mouthwash, while the tongue and oral mucosa were smeared with nystatin Glycerin, a day ban drinking, fasting. After a course of treatment, the number of positive cases of throat swab mold smear was observed in both groups. Results Two of the patients in the observation group (3.85%) showed positive results, while 9 (21.43%) of the patients in the control group showed positive results. The positive rate of the two groups has a more significant difference, with statistical significance (P <0.01). Conclusions If budesonide inhalation is used in patients with AECOPD, oral care must be intensified. Oral nystatin glycerol and 4% sodium bicarbonate solution should be gargled. The medicine cost is low and dosage is low, which can effectively reduce the patients’ Pain, can effectively prevent the effect of oral mold infection.