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目的研究长效β2受体激动剂治疗哮喘急性发作时的疗效,同时观察血管内皮生长因子的变化情况。方法选择76例哮喘急性发作患者随机分成两组,A组(只吸入激素),B组(吸入激素+长效β2受体激动剂),比较两组的治疗效果。观察1周后2组患者的血管内皮生长因子、血清嗜酸性粒细胞计数等。结果治疗1周后患者呼吸频率、血清的嗜酸性粒细胞计数及血管内皮生长因子、夜间憋醒次数、1周所需吸入短效β2受体激动剂的次数与A组比较差异有统计学意义(P<0.05)。结论吸入激素联合长效β2受体激动剂对哮喘急性发作期治疗安全有效,且长效β2受体激动剂具有一定的抗炎作用。血管内皮生长因子与支气管哮喘疾病密切相关。
Objective To study the efficacy of long-acting β2-agonist in the treatment of acute asthma attacks and to observe the changes of vascular endothelial growth factor. Methods Sixty-six patients with acute asthma were randomly divided into two groups: group A (inhaled hormone only) and group B (inhaled hormone + long-acting β2 receptor agonist). The therapeutic effects of the two groups were compared. After 1 week, the vascular endothelial growth factor and serum eosinophil count were observed in two groups. Results One week after treatment, the respiratory rate, serum eosinophil count, vascular endothelial growth factor, number of nighttime arousal, and the number of inhaled short-acting β2 agonists required for 1 week were significantly different from those in group A (P <0.05). Conclusion Inhaled hormones combined with long-acting β2 agonists are safe and effective in the treatment of acute exacerbation of asthma, and long-acting β2 agonists have some anti-inflammatory effects. Vascular endothelial growth factor and bronchial asthma disease are closely related.