半个世纪来奎尼丁和地高辛经常合用,曾成功治愈了多种心脏疾患。但近来的一些研究报告表明,两药合用时地高辛血浆浓度可增加两倍,不良反应也随之升高。实验观察发现:两药合用时地高辛的半衰期无明显变动,而其它药动学指标都显著降低。据Davide报告,地高辛体内总清除率从3.08毫升/分/公斤降到1.96毫升/分/公斤肾清除养从1.64毫升/分/公 For half a century, quinidine and digoxin are often used together and have successfully cured many heart diseases. However, some recent studies have shown that the two drugs combined digoxin plasma concentration can be doubled, adverse reactions also increased. Experimental observation found that: two drugs combined digoxin half-life no significant change, while other pharmacokinetic parameters were significantly reduced. According to Davide, the total clearance of digoxin was reduced from 3.08 ml / min / kg to 1.96 ml / min / kg. Kidney clearance was 1.64 ml / min / kg