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长期抑酸治疗前需根除幽门螺杆菌 Ernst KuipersErasmus MC University Medical Center.Rotterdam. The Netherlands H.pylori在所有感染个体中都会引起慢性胃炎。这种持续性炎症可能导致胃腺体和某些特异性细胞丢失,随之大多数而非全部个体将缓慢发生肠化。H.pyloti阳性个体是否进展至萎缩性胃炎取决于宿主和菌株因素。在这一方面,酸分泌是一个重要的宿主因素。正常至高酸分泌与以胃窦为主的胃炎有关,并缓慢进展至腺体丢失。低酸分泌易导致以胃体为主的全胃炎,并较快进展至萎缩性胃炎。这已为许多前瞻性和横断面研究所证实,这些研究报道,在普通人
Helicobacter pylori eradication should be eradicated prior to long-term acid suppression treatment. Ernst Kuipers Erasmus MC University Medical Center. Rotterdam The Netherlands H.pylori causes chronic gastritis in all infected individuals. This persistent inflammation may lead to the loss of gastric glands and certain specific cells, followed by the slow, most frequent intestinal metaplasia. Whether H. pyloti positive individuals progress to atrophic gastritis depends on host and strain factors. In this regard, acid secretion is an important host factor. Normal to high acid secretion and stomach-based gastritis, and slow progress to the loss of glands. Low acid secretion easily lead to corpus-based total gastritis, and rapid progression to atrophic gastritis. It has been confirmed by many prospective and cross-sectional studies that these reports are reported in the general population