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1949年锂开始用于控制和预防躁狂情绪的发作。从那时起,有关锂对躁狂性精神病的治疗价值已有报道。并且,锂也可用于躯体疾病(如中性白细胞减少,阵发性头痛)的治疗。本文着重阐述锂在老年病人方面的应用。一、老年人的药代动力学临床观察发现,在老年病人中。锂的疗效和副作用发生在较小剂量及血浆浓度较低的情况下,故认为年龄是影响锂的药代动力学及药效学的一个因素。
Lithium began to be used in 1949 to control and prevent manic seizures. Since then, the therapeutic value of lithium on manic psychosis has been reported. And lithium can also be used for the treatment of somatic diseases (such as neutropenia, paroxysmal headache). This article focuses on the application of lithium in elderly patients. First, the clinical pharmacokinetics of the elderly Clinical observation found that in elderly patients. The efficacy and side effects of lithium occur at lower doses and in lower plasma concentrations, so age is one of the factors that affect lithium pharmacokinetics and pharmacodynamics.