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目的 观察口服培菲康后血浆氨含量及内毒素水平的变化。方法 采用CCl4 复合因素法建立肝硬化模型 ;鲎试剂法检测血浆内毒素 ;谷氨酸脱氢酶速率法检测血氨。结果 治疗组内毒素及血氨水平均明显低于肝硬化模型组 (P <0 .0 5 ) ,其中预防治疗组血氨低于晚期治疗组 (P <0 .0 1)。结论 益生菌制剂能够降低血浆内毒素及血氨 ,对肝硬化有良好的辅助疗效。
Objective To observe the change of plasma ammonia level and endotoxin level after oral administration of Peifei Kang. Methods CCl4 composite factor method was used to establish cirrhosis model; 鲎 reagent method was used to detect plasma endotoxin; glutamate dehydrogenase rate method was used to detect serum ammonia. Results The levels of endotoxin and blood ammonia in the treatment group were significantly lower than those in the liver cirrhosis model group (P <0.05). The level of serum ammonia in the preventive treatment group was lower than that in the advanced treatment group (P <0.01). Conclusion Probiotics can reduce plasma endotoxin and blood ammonia, and have a good adjuvant effect on cirrhosis.