锑酸葡甲胺(meglumine antimoniate,MA)是治疗内脏利什曼原虫病的常用药物,传统剂量(20mg/kg体重,最大限制剂量850mg/天)对合并Ⅰ型人类免疫缺陷病毒(HIV-1)感染的内脏利什曼原虫病疗效不佳,病原学治愈率不足50％,且常有复发。作者回顾分析了在西班牙南部按美国疾病控制中心(CDC)的无上限剂量疗法治疗该类患者的资料。25例患者系1993年10月至1997年11月间到西班牙Seville的两所大学附属 Meglumine antimoniate (MA) is a commonly used drug for the treatment of visceral Leishmaniasis. Traditional Chinese medicine (20 mg / kg body weight and maximum dose of 850 mg / day) 1) infection of visceral Leishmaniasis poor efficacy, etiological cure rate of less than 50%, and often recurrence. The authors retrospectively analyzed the data for top-less dose-based treatment of patients in the South of Spain under the American Center for Disease Control (CDC). Twenty-five patients were affiliated to two universities in Seville, Spain, from October 1993 to November 1997