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目的探讨原发性肺癌99Tcm-甲氧异丁基异氰(99Tcm-MIBI)显像与肺癌组织中谷胱甘肽S转移酶π(GST-π)、DNA拓扑异构酶Ⅱa(TopoⅡa)表达的关系。方法对34例原发性肺癌患者术前行早期与延迟99Tcm-MIBI显像,应用免疫组织化学方法检测术后标本中多药耐药蛋白GST-π、TopoⅡa的表达水平。比较早期摄取比值(EUR)、晚期摄取比值(DUR)及放射性清除指数(WR)与GST-π、TopoⅡa表达的关系。结果99Tcm-MIBI早期、延迟显像阳性率分别为89.5%、82.4%,GST-π、TopoⅡa表达阳性率分别为78.5%、61.7%,GST-π、TopoⅡa表达阳性组和阴性组间EUR、DUR、WR差异均无统计学意义(P>0.05)。结论99Tcm-MIBI显像与肺癌组织中GST-π、TopoⅡa表达无相关性,不具有检测肺癌患者肿瘤组织中GST-π、TopoⅡa表达的价值。
Objective To investigate the relationship between 99Tcm-methoxy-isobutyl-isocyanide (99Tcm-MIBI) imaging and the expression of glutathione S-transferase π (GST-π) and topoisomerase Ⅱ a (TopoⅡa) in primary lung cancer. Methods Thirty-four patients with primary lung cancer underwent early and delayed 99Tcm-MIBI imaging. The expression of multidrug resistance protein GST-π and TopoⅡa in the specimens were detected by immunohistochemistry. The relationship between early intake ratio (EUR), late intake ratio (DUR) and radioactive clearance index (WR) and GST-π, TopoⅡa expression was compared. Results The positive rate of 99Tcm-MIBI in delayed imaging was 89.5% and 82.4% respectively, and the positive rates of GST-π and TopoⅡa were 78.5% and 61.7% respectively. The positive rates of EUR, DUR and GST- , WR difference was not statistically significant (P> 0.05). Conclusion There is no correlation between 99Tcm-MIBI imaging and expression of GST-π and TopoⅡa in lung cancer tissues. It does not have the value of detecting the expression of GST-π and TopoⅡa in lung cancer.